In this scenario, curcumin represents a promising candidate as an effective anticancer drug to be used alone or in combination with other drugs. It is worth noting that cancer cells are characterized by deregulated signaling pathways involving proliferation, apoptosis, and angiogenesis. However, the growth of drug-resistant cancers necessitates the search for innovative and more effective drugs. In recent years, the early diagnosis and increase in therapeutic options has reduced the death rate. However, the abovementioned activities seem to be due mostly to the antioxidant and anti-inflammatory effects of curcumin.Ĭancer is one of the primary causes of death in industrialized countries. As a result of a recent bibliographic research, we found 12,595 papers on curcumin (1924–2018) and 4738 (1983–2018) of which were on curcumin and cancer that means 37% of the published papers on curcumin has cancer as the major targeted disease ( ). The therapeutic benefits of curcumin have been demonstrated in multiple chronic diseases: inflammation, arthritis, metabolic syndrome, liver disease, obesity, neurodegenerative diseases and, above all, in several cancers. The chemistry of curcumin is at the basis of its several biological activities. Since then, the scientific interest towards curcumin has increased and, more and more, its health benefits have been discovered.Ĭurcumin belongs to a chemical class of polyphenols it is known as diferuloylmethane and its IUPAC name is (1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, with a chemical formula of C 21H 20O 6 and a molecular weight of 368.38. It was isolated for the first time in 1815 by two scientists, Vogel and Pelletier, from Harvard College Laboratory. The most representative polyphenol component extracted from the rhizomes of Curcuma longa (known as turmeric) is curcumin.

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